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Notably, thyroid hormones may facilitate augmented carnitine synthesis in the liver by increasing -butyrobetaine hydroxylase (BBD) activity and gene expression, which may constitute a feedback regulatory loop between thyroid hormones and carnitine [80]

Large-scale clinical studies in humans are still required to confirm their safety, efficacy, and potential therapeutic value

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Fasting is defined as no caloric intake for at least eight hours

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EPR spectra of GHK-Cu typically display axial symmetry with g 2.20 and A 190 10 cm, consistent with square-planar or elongated octahedral geometry