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Lilly noted, however, that dropouts were highly correlated with baseline BMI and included discontinuations for perceived excessive weight loss. The company also pointed out that participants with a higher BMI were less likely to drop out

For most patients, a single well-dosed GLP-1 agent produces the weight loss they're seeking while improving metabolic markers like fasting glucose and lipid profiles

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Finally, we show that in women taking either semaglutide or tirzepatide, elevated circulating estradiol levels are predictive of nausea and vomiting risk

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The trials did show improvement in biomarkers associated with the disease, which is why the result is more interesting than a flat failure: the drug was doing something biologically, but that something did not reach the patient as a slower decline