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Loss of Strength and Coordination Research shows muscle quality may decline with GLP-1 use, not just size
To find out, we asked the experts
Diabetes Obes Metab 14:514 Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, The PROactive Investigators (2005) Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive study (PROspective pioglitAzone clinical trial in macro vascular events): a randomised controlled trial
The study conducted by Zulfiqar et al
doi: 10.3109/03602532.2010.527984
Overall, the data demonstrate that ACLY and ACSS2 are not the sole sources of acetyl-CoA in the nuclear-cytosolic compartment, and that the carnitine shuttle participates in the transit of acetyl-CoA from mitochondria to cytosol to support lipogenesis and histone acetylation
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