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In TME, ferroptosis activates the NLRP3 inflammasome and cytokine release, thereby enhancing the inflammatory response and promoting immune evasion (40)

In vitro studies suggested that genistein treatment of human keratinocytes and fibroblasts modulates glutathione content and reactive oxygen species release, endothelial/inducible (e/i)NOS dependent nitric oxide release, MMP expression, and mitochondria membrane potential through mechanisms involving p38 MAPK, AKT and ERK1/2 as downstream signaling associated with membrane ERs and GPER, as well as by increasing SOD activity and BCL2 expression in endothelial cells (Savoia et al., 2018

J Family Reprod Health

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This can cause a variety of symptoms, including tingling, numbness, burning, poor balance, and walking difficulties