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These studies established the link between oxidative stress and inflammatory response in specific cell types in the brain during chronic alcohol ingestion, validating our recent findings that ethanol metabolism causes a significant induction of iNOS protein level in primary human neurons [17]

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*Source: Xu, P., Liu, L., Zeng, G

The conversion of tyrosine into methoxy tyrosine and dimercaprol into methylated form are examples of O-methylation and S-methylation respectively (Figure 17)