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The treatment effect was then evaluated using Cox proportional hazard regression, with cage assignment included as a random effect and batch as a covariate, using statistical software R (version 3.4.1) with package coxme

These glycaemic fluctuations can influence gut microbiota composition by selectively promoting the growth of glucose-utilizing bacteria while suppressing beneficial fiber-fermenting species

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The results were presented at the American Diabetes Association (ADA) 85th Scientific Sessions 2025 and simultaneously published in The New England Journal of Medicine

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Decisions about Zepbound treatment duration should always involve collaborative discussion with your healthcare provider, considering your individual circumstances, goals, and medical history