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In yet other embodiments, the formulation or composition provides an immediate release and extended release formulation or composition of at least one otic agent, and at least one therapeutic agent

In an in vitro model of neural stem cell-derived neurons (NSCN), ketamine has been reported to decrease the phosphorylation of glycogen synthase kinase 3 (GSK-3), which could lead to apoptosis [119]

Wada F, Koga H, Akiba J, Niizeki T, Iwamoto H, Ikezono Y, et al

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A number of nonenzymatic and enzymatic antioxidant defense mechanisms are responsible for neutralizing ROS