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A recent study further demonstrated that proline catabolism via PRODH supports 3D growth of breast cancer cells, with elevated PRODH expression and proline oxidation in metastatic lesions compared with primary tumors, thereby promoting metastatic colonization and identifying PRODH as a potential target for metastasis suppression 64

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Wu PJ, Chen JB, Lee WC et al (2018) Oxidative stress and nonalcoholic fatty liver disease in hemodialysis patients

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NCG is used to stimulate the residual activity of enzymes in the urea cycle