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Kalavalapalli S, Leiva EG, Lomonaco R, Chi X, Shrestha S, Dillard R, et al

Beta-cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1

24.2% weight loss at 48 weeks This figure from the NEJM 2023 Phase 2 trial is the most-cited data point for Retatrutide

And since obesity is chronic, weight regains are shown to occur when stopping the medication

Although these observations are interesting, the comparison with historical control individuals is a serious limitation in the interpretation of these results

LEXI LOCH , ND, is an author, educator and integrative medicine practitioner