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The reconstituted solution is more vulnerable to degradation than the lyophilized powder

The primary outcome was major adverse cardiovascular events (a composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke), assessed in a time-to-first-event analysis

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Semaglutide and newer GLP-1s are more powerful but come with a higher chance of side effects and a steeper price tag

Any mechanical irregularity should raise concern

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