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Pre-publication history The pre-publication history for this paper can be accessed here: Additional information Competing interests The authors declare that they have no competing interests

In individuals with T2DM, chronic hyperglycemia is known to downregulate GIPR expression and impair GIP-stimulated insulinotropic activity, thereby limiting the efficacy of GIP monotherapy [21]

Fact: Antioxidants work best in a network

Three landmark trials (Action to Control Cardiovascular Risk in Diabetes [ACCORD], Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation [ADVANCE], and Veterans Affairs Diabetes Trial [VADT]) were conducted to test the effects of near normalization of blood glucose on cardiovascular outcomes in individuals with long-standing type 2 diabetes and either known cardiovascular disease (CVD) or high cardiovascular risk

Sian J, Dexter DT, Lees AJ, et al

A short course of anti-nausea medication can carry someone through a hard week of titration