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It has features of both an autoimmune disorder and a neurodegenerative condition, which makes it a particularly interesting case for the MGBA [180]

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This toxicity is characterized by specific microbial alterations and disrupted bile acid metabolism

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The combination is why early trial results have been striking

Compared with the TPA + TNF- group, the fluorescence intensity of the si-NC-treated cells in the TPA-treated group was greater, but the fluorescence intensity of the si-TR1 cells was similar across the TPA + TNF- group and TPA group(Fig