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For people with absorption issues (and most adults over 50 have at least some), oral B12 simply doesnt deliver enough cobalamin to make a felt difference

When paired, the result isnt stimulation its improved utilization

Crit Rev Biochem Mol Biol (1995) 30:445520

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At two 25-unit (0.25 mL) doses per day, they use 0.5 mL per day

G., Collins, J