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10.1097/ACI.0b013e3282f3d913

Individuals with two copies (homozygous) have about 3040% of normal enzyme activity

General skincare measures can help support skin barrier function and reduce sensitivity: Moisturise regularly using fragrance-free, hypoallergenic emollients to maintain skin hydration, particularly if dryness accompanies weight loss Avoid harsh skincare products containing alcohol, strong fragrances, or exfoliating acids, which may exacerbate sensitivity Use broad-spectrum SPF 30+ sunscreen daily as a general skin protection measure, and limit prolonged sun exposure Wear loose, breathable clothing to minimise friction against sensitive skin areas Apply a cool compress to injection site reactions to help reduce localised redness or discomfort Maintain a balanced diet in line with the NHS Eatwell Guide

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In myoblast culture models, researchers observed that IGF-1 LR3 is associated with increased myotube formation, protein synthesis rates, and satellite cell activation markers