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This lack of energy may make it difficult for individuals to engage in regular physical activity, potentially leading to weight gain

doi: 10.1094/MPMI.2004.17.9.976 10 CuttJ

DSIP readily crosses the blood-brain barrier to exert central effects and may enhance inhibitory neuronal activity or modulate sleep-regulating brain regions

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320, E191e207

Tirzepatide is an imbalanced agonist, engaging the GIPR to a greater degree than the GLP-1R in cultured cell systems