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The status of the 3 patients in the 2 early case reports was fragile because of fatal diseases: 2 had advanced breast cancer with metastases and 1 had multiple diseasescolitis or cholecystitis, achlorhydria, degenerative arthritis, and cholelithiasiswith severe right upper-quadrant pain

Athletes and active individuals should not exceed the maximum daily dose even with frequent exercise

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Regular follow-ups with healthcare providers can help ensure that the treatment remains effective and safe, allowing for any necessary adjustments to be made based on the patient's response