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LY3298176 was characterised in vitro, using signaling and functional assays in cell lines expressing recombinant or endogenous incretin receptors, and in vivo using body weight, food intake, insulin secretion and glycemic profiles in mice

10.1038/srep06569 154 SadraieS

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Using recombinantly purified enzymes, enantiomer-specific formation of D-malate by the NAD(P) + -dependent malic semialdehyde dehydrogenase (MSA-DH) is demonstrated

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