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A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19

It is also worth noting that not all Vitamin C forms are equal in this regard

doi:10.1007/s00204-012-0924-1 Hinson JA, Roberts DW, James LP (2010) Mechanisms of acetaminophen-induced liver necrosis

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In addition, the risk of hepatotoxicity substantially increases with APAP concentrations over 300mcg/mL

In systemic in vivo research (animal models of wound healing, tissue regeneration) it is used by injection (subcutaneously, intraperitoneally) at doses typically 1 to 10 mg/kg daily for 2 to 6 weeks