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Do not double the dose

For instance, it has been reported that hypothyroidism-induced dysfunction of the mitochondrial respiratory chain is associated with increased production of free radicals (59) Thus, excess TSH in hypothyroidism may modulate oxidative stress processes (60) by augmenting the accumulation of ROS that result from both increased generation of free radicals and diminished capacity of the antioxidative defense systems

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doi: 10.1016/j.biopha.2020.110108 61 KobayashiSHamashimaSHommaTSatoMKusumiRBannaiSet al

Curcumin-loaded hydroxypropyl--cyclodextrin inclusion complex with enhanced dissolution and oral bioavailability for epilepsy treatment