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8.5 Reimbursement and health technology assessment Reimbursement considerations increasingly influence drug development strategy from early stages ( Conversely, peptides developed solely on the basis of biomarker changes without clear clinical relevance may face reimbursement challenges regardless of regulatory approval ( 8.6 Scientific integrity and responsible framing From a scientific-integrity standpoint, the renewed interest in underexplored peptide systems carries an obligation to avoid overstated claims and selective citation

These biological processes may contribute to healthy aging, cellular repair, and circadian rhythm regulation

Annu Rev Biochem 73 : 87106

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