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As a mitochondrial-derived peptide , it acts as a retrograde signal , meaning it can communicate metabolic conditions from the mitochondria to the nucleus, thereby influencing gene expression and cellular metabolism

Saande CJ, Steffes MA, Webb JL, Valentine RJ, Rowling MJ, Schalinske KL

The Fraxel laser is best for patients with light skin tone and to be avoided in patients with dark skin tones

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