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This work, together with our previous findings using the drug raloxifene, demonstrates that pharmacologically delaying SG disassembly impairs timely stress resolution and leads to increased GBM cell death

Ca 2+ is a master regulator of eryptosis, mediating the Gardos effect-associated RBC dehydration and reduction of cell volume (cell shrinkage), calpain activation-mediated cytoskeleton remodeling (membrane blebbing), and PS externalization, which are major hallmarks of eryptosis

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This effect is particularly evident in clinical studies of patients undergoing bariatric surgery

29 Complex I produces most of the superoxide that is generated by mammalian mitochondria in vitro