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Document history Updated in August 2025 by Lisa Dal Pozzo (Mechanism of Action and Safety) and the CAM Cancer Collaboration

35 , 36 As renal function deteriorates, TMAO level increases and correlates with coronary atherosclerosis burden, 35 gut microbiota alterations, increased intestinal permeability, chronic inflammation, and endothelial dysfunction

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Adverse effects have not been reported with the normal daily intake of ascorbic acid, vitamin C within the recommended dietary daily intakes for a pregnant female