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Direct answer: Long-term Semaglutide use may include persistent gastrointestinal symptoms, potential muscle loss, gallbladder issues, and rare risks like pancreatitis or thyroid concerns

Congenital deficiency of any of the six enzymes within this cycle N -acetylglutamate synthase (NAGS), carbamoyl phosphate synthase I (CPS), ornithine transcarbamylase (OTC), argininosuccinate synthetase (ASS), argininosuccinate lyase (ASL) and arginase 1 will result in a build-up of both ammonia and the substrate of the specific enzyme 4

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