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While recent randomized clinical trials have rightly generated a lot of interest in GLP-1 agonists, having these results, specifically reduction in the composite outcome of heart failure hospitalizations and all-cause mortality, replicated in a large cohort study will likely increase their utilization even before we see a change in guidelines, she told Healthline

Thousands of people self-administering compounded semaglutide or brand-name formulations wonder this exact thing every single week