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To determine whether these BAL fluid levels were a reflection of intracellular GSH metabolism, freshly brushed and isolated HAECs were analyzed and compared to BAL fluid levels (Figure 1B)

doi: 10.1038/s41392-024-01757-9 94 AlanaziFJAlruwailiANAldhafeeriNABallalSSharmaRDebnathSet al

10.1038/s41467-023-40518-0 119 YadavS.ChawlaB.KhursheedM

Our initial attempts to hydrophobize the surface of GSH-AuNCs suggested a ligand exchange reaction to displace the glutathione molecules with a hydrophobic thiolated ligand (e.g

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Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025