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The Common Drug Review (CDR) process through CADTH will determine whether provinces add retatrutide to their formularies

Semaglutide demonstrates superior weight loss and glycemic control compared to other GLP-1 receptor agonists like liraglutide and exenatide, with clinical trials showing enhanced patient adherence through once-weekly dosing

Primarily, it stimulates insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning insulin is released only when blood glucose levels are elevated

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Preferring daily tablets over weekly injections