3 Patients on GLP-1s had a median HbA1c reduction of 0.5 points, while those on metformin had a median HbA1c reduction of 0.1 points
Vorkas, C
However, simply showing that the enzyme can cleave a substrate in vitro does not necessarily mean that DPP-4 plays an important physiological role in regulating concentrations and/or modulating biological activity of the endogenous molecules, particularly in humans and, for many of these putative substrates, there is little, if any experimental evidence to show that DPP-4 does actually cleave them in vivo and/or whether this has any physiological consequence
If you are already established on the medication, select the plan that aligns with your current weekly dose
For supply shortages, consult your healthcare provider about switching to a different formulation or exploring similar GLP-1 receptor agonists
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