Canagliflozin was associated with a decrease in total hip bone mineral density over 104 weeks, (placebo-subtracted changes:100mg -0.9% and 300mg -1.2%), but did not result in changes in bone mineral density in the femoral neck, lumbar spine, or distal forearm (227)
8.3 Females and Males of Reproductive Potential Discuss the potential for unintended pregnancy with premenopausal women as therapy with metformin may result in ovulation in some anovulatory women
That said, the practical picture is less appealing
Treatment with MTZ quickly changes hepatic B cell populations, increasing the retention of innate-like B cells that express CXCR3 and produce a more anti-inflammatory effect
In the study, the greatest reduction in colorectal cancer risk was seen in younger adults
Diabetes Healthcare Professionals Consider Whole Person As diabetes healthcare professionals, we want to carefully consider which medication best matches the people in our care, considering individual values and preferences along with co-conditions including diabetes, cardiorenal metabolic co-conditions, MASH, sleep apnea and weight goals