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NICE guidance recommends intramuscular hydroxocobalamin as first-line treatment for B12 deficiency caused by pernicious anaemia or malabsorption

Additionally, in breast cancer, PHGDH interacts with glycolytic enzyme phosphofructokinase platelet isoform (PFKP)

Further analysis of the ongoing trials should eventually demonstrate the impact of these drugs on the natural history of the disease and their potential for improving quality of life, promoting fibrosis regression, and reducing extrahepatic and hepatic cancer along with a decline in hepatic decompensation rates