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We therefore postulated that IGF-1R mAbs could represent a viable therapeutic tool to target IGF-1 action, and potentially mimic the beneficial effects associated with diminished IGF-1 signaling observed in animal models

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Other studies investigated the relationship between serum IGF-1 levels and the prevalence of depressive disorders

Concurrent ICV administration of GLP- 1 and GIP significantly increased neuronal activation and pro-opiomelanocortin expression in the arcuate nucleus of the hypothalamus

The TTrials showed significant increases in bone mineral density and estimated bone strength, particularly in the spine and hip