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Together, these findings highlight histone crotonylation as a stress-sensitive epigenetic mechanism that regulates synaptic plasticity and depressive-like behaviors, primarily via CDYLEZH2VGF signaling

Phytoestrogens are mostly beneficial to the processes of proliferation and differentiation of NSPCs

All authors are agreed in their accountable contributions and approval of the manuscript

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Klonoff DC, Buse JB, Nielsen LL, et al