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To our surprise, treatment with MitoQ at 100 nM, as suggested by previous studies 16, 21 , did not reduce but drastically increased mitochondrial ROS level (Fig

It also supports DNA repair in UV-irradiated melanocytes by upregulating essential repair genes such as SIRT1 and p53, while simultaneously activating the Nrf2 signaling pathway 184,185

Fold relative enrichment is shown using the 67NR or the D2A1 cells as comparator ( n = 3 biological replicates in either single or technical duplicate)