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In rodent satellite-cell models, sustained IGF-1R activation by long-acting analogues increased myotube diameter by 30-40% compared with vehicle, an effect attenuated by the PI3K inhibitor LY294002 [5]

Diabetes 62 , 15271536 (2013)

Improved radiochemical assay for carnitine and its derivatives in plasma and tissue extracts

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Rather than targeting more receptors with a single molecule, it combines two separate compounds, cagrilintide (an amylin analogue) and semaglutide (a GLP-1 agonist), into a single weekly injection