If you havent yet, I recommend watching or re-watching my video about what GLP-1 is and how it works, to best fully grasp the issue at hand
Carotenoid derivates in achiote (bixa orellana) seeds: synthesis and health promoting properties
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The body uses calories to stay alive, complete workouts, and get through everyday activities
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To achieve a plasma level of 0.7mM (less than the 1mM used int he paper), you have to give a rat 150mg/kg/day IV, which is the equivalent of a 1451mg IV SAMe daily dose to a 60kg human, but since the oral absorption is around 5%, that's the equivalent of more than a 29,000mg daily oral dose