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The difference from placebo (95% CI) for semaglutide tablets 14 mg was -2.5 kg (-3.2, -1.8)

Repeated use of the same site: Injecting in the same area repeatedly can increase irritation and sensitivity

Some providers may start at 5 mg if you were on high-dose semaglutide, but 2.5 mg is the conservative and generally recommended approach

Patients with more pronounced insulin resistance or higher baseline weight may show continued benefit from higher doses

Data analyses didnt reveal a significant difference when comparing the untreated Pla2g6 / mice to the Pla2g6 / group treated with high-dose semaglutide, except for a significant decrease in the freezing time at 12 weeks