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When applied, the spray is absorbed via nasal membranes, promoting a gradual darkening of the skin

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doi: 10.1074/jbc.M500166200

Other common side effects of the drug patients experience include: Nausea (in 29-34% of patients, depending on the dosage) Constipation (22-25%) Diarrhea (21-23%) and vomiting (13-24%) Over the course of the trial, Salberg committed to other healthy lifestyle changes

[PMC free article: PMC3985831] [PubMed: 24598885] 24