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The Journal of the American Osteopathic Association 2011;111:eS1520 Shuey MM, Lee KM, Keaton J, Khankari NK, Breeyear JH, Walker VM, Miller DR, Heberer KR, Reaven PD, Clarke SL, Lee J, Lynch JA, Vujkovic M, Edwards TL

The epithelial barrier represents the subsequent challenge, as peptides are unable to cross the epithelium (transcellular transport) or tight junctions (paracellular transport) by passive diffusion, due to their size and hydrophilicity

Theoretical concerns include growth factor-related effects in individuals with existing malignancies and immune modulation in vulnerable populations

10.1161/JAHA.121.024521 33

Bykov I, Jrvelinen H, Lindros K: L-carnitine alleviates alcohol-induced liver damage in rats: role of tumour necrosis factor-alpha