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Its preservatives and sterile integrity decrease with time and this may affect safety

Our major findings were that the ventilatory depressant effects and negative changes in ABG chemistry and A-a gradient elicited by fentanyl were markedly attenuated in rats pretreated with GSHee

Taking into account data from 2011 to 2015 (for Norway), increasing consumption of atypical antipsychotics can be noticed (diazepines, oxazepines, thiazepines, and others such as aripiprazole), while sales of typical antipsychotics are decreasing (this statement refers especially to the phenothiazine derivatives with a piperazine side chain) (Norwegian Institute of Public Health 2016)

10.1016/s0889-857x(05)70109-5 69 Sahelk

An experimental model of neuromyelitis optica spectrum disorder-optic neuritis: insights into disease mechanisms