For persistent pigmentation-driven dark circles where melanin production has been occurring over years of UV exposure or inflammation, the upstream intervention is more effective than downstream distribution inhibition alone
Under normal circumstances, the body uses specialized enzymes to neutralize this stress immediately
[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Ganguli M, Snitz BE, Saxton JA, Chang CC, Lee CW, Vander Bilt J, Hughes TF, Loewenstein DA, Unverzagt FW, Petersen RC
Balance with copper intake for long-term use
*Antioxidants alone will not be effective in the majority of melasma cases
Notably, the PBS + laser group exhibited a decrease in pro-inflammatory factors compared to the PBS, suggesting that NIR light alone has a certain anti-inflammation effect