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Over 84 weeks in 809 patients, CagriSema delivered 23% mean weight loss versus 25.5% for tirzepatide

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Leveraging the University of California Health Data Warehouse enabled a realworld analysis of 6,871 patients with primary colon cancer and rigorous adjustment strategies to probe whether GLP1 RA exposure relates to fiveyear mortality. At the end of the study, researchers found that participants with colon cancer taking GLP-1 medications had a 15.5% mortality risk within 5 years, compared to 37.1% in participants not taking the drugs

Although PPAR/ co-agonists have shown metabolic benefits in clinical trials, many have been discontinued owing to adverse cardiovascular and/or renal effects 10,11,23

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