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doi: 10.1073/pnas.1207169109 116 GoreACThompsonLMBellMMennigenJA

Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic alpha-cells in mouse models of ss-cell regeneration

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Peptides do not have equivalent human evidence

In the current study, 4/18 (22%) not detected samples were classified as 1d, 1e, 1g, and 1h by sequencing, while the proportion of non-1a non-1b subtypes was higher in the study by Mokhtari et al

Though IL-6 has pro-inflammatory functions, it can also stimulate the release of IL-10 (Ostrowski et al., 1999) which in turn inhibits the production of inflammatory cytokines such as IL-1, and tumour necrosis factor- (TNF-) (Liu et al., 2020)