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Serum metabolomics identifies dysregulated pathways and potential metabolic biomarkers for hyperuricemia and gout

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More muscle means higher basal metabolic rate

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The NF-B pathway is activated by pro-inflammatory factors such as TNF- and IL-6 [24], enhancing transcriptional activity through receptor-mediated downstream signaling cascades, inducing the expression of E3 ubiquitin ligase genes atrogin-1 and MuRF1, thereby driving muscle protein degradation via the UPS [25]