Starting is easy
doi: 10.1056/NEJMoa0802987
Each additional receptor system contributes a distinct physiological mechanism: GIP adds an incretin and adipose tissue dimension that semaglutide lacks
Xu H, Liu T, Hu L, Li J, Gan C, Xu J, Chen F, Xiang Z, Wang X, Sheng J (2019) Effect of caffeine on ovariectomy-induced osteoporosis in rats
Glutamine improves HSP70 and HSP27 expression [43, 44, 110] and acts not only as a modulator of the heat shock response but also as a competent inducer of HSF-1 expression, activating its transcription [93, 111, 112]
Loomba R et al., SYNERGY-NASH, NEJM 2024 (NEJMoa2401943, PMID 38856224) : tirzepatide and MASH, resolution in 62% at the 15 mg level