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Redefining Knee Osteoarthritis Management: The Role of Retatrutide In the TRIUMPH-4 trial , retatrutide produced mean weight loss up to 28.7% at 68 weeks and an average 75.8% reduction in WOMAC pain versus placebo effect sizes that, if confirmed, could reshape care for obesity-related knee osteoarthritis

TB-500 corresponds to its central active 17-mer fragment (sequence LKKTETQ), responsible for most pro-regenerative effects