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The most important factor is consistency

1 2 Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists

Additionally, Amifostine must be administered in a narrow time window (1530 min) before each radiation dose because of its short half-life 16 , constraining its clinical use 17

This way, they can make sure patients get the best care possible

Periorbital wrinkles, hydration, and skin elasticity improved at 4, 8, and 12 weeks in the collagen supplement group compared with baseline or placebo-control values

Under a non-monotonic curve, an increase producing less effect is ambiguous: it cannot distinguish being below the peak from having passed it