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Infections, medications, alcohol, liver disease, bone-marrow disorders, and other autoimmune conditions

Cells were subjected to treatment in incubator for 24 hr

Some researchers attempt to salvage marginally exposed vials by immediately returning them to 28C and using them within 7 days rather than the standard 28-day window, but this creates uncertainty in downstream data

Balance problems and coordination difficulties typically require longer treatment periods

Cost and availability often make cyanocobalamin a pragmatic first-line option

Central & peripheral nervous-system models TBI, stroke, peripheral nerve transection