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135, 2018 [18] D

OCTN2 is also critical for efficient renal tubular reabsorption of carnitine, where the vast majority of filtered carnitine (and short-chain acyl derivatives of carnitine) are reabsorbed 5,6,7

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Important safety considerations include gastrointestinal side effects (nausea, vomiting, diarrhoea), risk of gallbladder disease, pancreatitis, dehydration leading to acute kidney injury, and worsening diabetic retinopathy with rapid glycaemic improvement

This deficiency is common, affecting approximately 6% of people under the age of 60 and 20% of people over the age of 60