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However, this risk has not been demonstrated in humans at therapeutic doses, and the warning is being reevaluated based on post-marketing surveillance data

doi: 10.1055/s-0034-1375954

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But the same review goes on to note that certain topical amino acids namely, arginine have demonstrated the ability to enhance collagen production and improve the skin barrier in humans when applied topically.42 Ceramides Ceramides can do quite a bit for your skin health

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Cancer 12 (8), 12191230