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This demographic trend has significant biological implications, as female fertility begins to decline around 30 years of age and accelerates dramatically after 35 [1, 2]

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Then the larger TriNetX analysis presented at ACR 2025 more than 12,000 semaglutide users, propensity-matched showed lower risk of stiffness, swelling, pain, and synovitis at 30 days, 3 months, and a year

Below 0.3%, preservation is effectively absent